Novel Small-Molecule Inhibitors of the SARS-CoV-2 Spike Protein Binding to Neuropilin 1

• Autores principales: Anja Kolarič (Autor), Marko Jukič (Autor), Urban Bren (Autor)
• Formato: Libro
• Publicado: MDPI AG, 2022-01-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Furin cleavage of the SARS-CoV-2 spike protein results in a polybasic terminal sequence termed the C-end rule (CendR), which is responsible for the binding to neuropilin 1 (NRP1), enhancing viral infectivity and entry into the cell. Here we report the identification of 20 small-molecule inhibitors t...