Can successful pregnancy be achieved and predicted from patients with identified ZP mutations? A literature review

• Main Authors: Juepu Zhou (Author), Meng Wang (Author), Qiyu Yang (Author), Dan Li (Author), Zhou Li (Author), Juan Hu (Author), Lei Jin (Author), Lixia Zhu (Author)
• Format: Book
• Published: BMC, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background In mammals, normal fertilization depends on the structural and functional integrity of the zona pellucida (ZP), which is an extracellular matrix surrounding oocytes. Mutations in ZP may affect oogenesis, fertilization and early embryonic development, which may cause female infert...