Synthesis of taurine-fluorescein conjugate and evaluation of its retina-targeted efficiency in vitro

• Ngā kaituhi matua: Meihong Huang (Author), Jiaqi Song (Author), Bingzheng Lu (Author), Huizhi Huang (Author), Yizhen Chen (Author), Wei Yin (Author), Wenbo Zhu (Author), Xinwen Su (Author), Chuanbin Wu (Author), Haiyan Hu (Author)
• Hōputu: Pukapuka
• I whakaputaina: Elsevier, 2014-12-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

In this work, retinal penetration of fluorescein was achieved in vitro by covalent attachment of taurine to fluorescein, yielding the F-Tau conjugate. Nuclear magnetic resonance (NMR) and high resolution mass spectrometry (HRMS) were used to confirm the successful synthesis of F-Tau. The cellular up...