Optimizing the dosing schedule of l-asparaginase improves its anti-tumor activity in breast tumor-bearing mice

Proliferation of acute lymphoblastic leukemic cells is nutritionally dependent on the external supply of asparagine. l-asparaginase, an enzyme hydrolyzing l-asparagine in blood, is used for treatment of acute lymphoblastic leukemic and other related blood cancers. Although previous studies demonstra...

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Main Authors: Shoya Shiromizu (Author), Naoki Kusunose (Author), Naoya Matsunaga (Author), Satoru Koyanagi (Author), Shigehiro Ohdo (Author)
Format: Book
Published: Elsevier, 2018-04-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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