Optimizing the dosing schedule of l-asparaginase improves its anti-tumor activity in breast tumor-bearing mice

• Päätekijät: Shoya Shiromizu (Tekijä), Naoki Kusunose (Tekijä), Naoya Matsunaga (Tekijä), Satoru Koyanagi (Tekijä), Shigehiro Ohdo (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Elsevier, 2018-04-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Proliferation of acute lymphoblastic leukemic cells is nutritionally dependent on the external supply of asparagine. l-asparaginase, an enzyme hydrolyzing l-asparagine in blood, is used for treatment of acute lymphoblastic leukemic and other related blood cancers. Although previous studies demonstra...