Elucidating nonlinear pharmacokinetics of telmisartan: Integration of target‐mediated drug disposition and OATP1B3‐mediated hepatic uptake in a physiologically based model
Abstract Telmisartan, a selective inhibitor of angiotensin II receptor type 1 (AT1), demonstrates nonlinear pharmacokinetics (PK) when orally administered in ascending doses to healthy volunteers, but the underlying mechanisms remain unclear. This study presents a physiologically based pharmacokinet...
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| Main Authors: | , , , , , |
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| Format: | Book |
| Published: |
Wiley,
2024-07-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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