Role of CYP2C9, CYP2C19 and EPHX Polymorphism in the Pharmacokinetic of Phenytoin: A Study on Uruguayan Caucasian Subjects

• Main Authors: Natalia Guevara (Author), Cecilia Maldonado (Author), Manuel Uría (Author), Raquel González (Author), Manuel Ibarra (Author), Silvana Alvariza (Author), Antonella Carozzi (Author), Carlos Azambuja (Author), Pietro Fagiolino (Author), Marta Vázquez (Author)
• Format: Book
• Published: MDPI AG, 2017-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Phenytoin (PHT) oxidative route leads to its main metabolite p-hydroxyphenytoin (p-HPPH), by means of CYP2C9 and CYP2C19. Formation of p-HPPH proceeds via a reactive arene-oxide intermediate. This intermediate can also be converted into PHT dihydrodiol by microsomal epoxide hydrolase (EPHX). The thr...