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Role of CYP2C9, CYP2C19 and EPHX Polymorphism in the Pharmacokinetic of Phenytoin: A Study on Uruguayan Caucasian Subjects

Phenytoin (PHT) oxidative route leads to its main metabolite p-hydroxyphenytoin (p-HPPH), by means of CYP2C9 and CYP2C19. Formation of p-HPPH proceeds via a reactive arene-oxide intermediate. This intermediate can also be converted into PHT dihydrodiol by microsomal epoxide hydrolase (EPHX). The thr...

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Main Authors:	Natalia Guevara (Author), Cecilia Maldonado (Author), Manuel Uría (Author), Raquel González (Author), Manuel Ibarra (Author), Silvana Alvariza (Author), Antonella Carozzi (Author), Carlos Azambuja (Author), Pietro Fagiolino (Author), Marta Vázquez (Author)
Format:	Book
Published:	MDPI AG, 2017-08-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
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