Possible Underlying Mechanisms Responsible for Aldosterone and Mineralocorticoid Receptor-Dependent Renal Injury

• Autori principali: Hideyasu Kiyomoto (Autore), Kazi Rafiq (Autore), Mahbub Mostofa (Autore), Akira Nishiyama (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2008-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

There is increasing evidence indicating the roles of aldosterone and mineralocorticoid receptor (MR) in the pathogenesis of renal injury. In rats, chronic treatment with aldosterone and salt results in severe proteinuria and renal tissue injury, characterized by glomerulosclerosis and tubulointersti...