Possible Underlying Mechanisms Responsible for Aldosterone and Mineralocorticoid Receptor-Dependent Renal Injury

• मुख्य लेखकों: Hideyasu Kiyomoto (लेखक), Kazi Rafiq (लेखक), Mahbub Mostofa (लेखक), Akira Nishiyama (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2008-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

There is increasing evidence indicating the roles of aldosterone and mineralocorticoid receptor (MR) in the pathogenesis of renal injury. In rats, chronic treatment with aldosterone and salt results in severe proteinuria and renal tissue injury, characterized by glomerulosclerosis and tubulointersti...