Evodiamine Augments NLRP3 Inflammasome Activation and Anti-bacterial Responses Through Inducing α-Tubulin Acetylation

• Main Authors: Chen-Guang Li (Author), Qiong-Zhen Zeng (Author), Ming-Ye Chen (Author), Li-Hui Xu (Author), Cheng-Cheng Zhang (Author), Feng-Yi Mai (Author), Chen-Ying Zeng (Author), Xian-Hui He (Author), Dong-Yun Ouyang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Evodiamine is a major ingredient of the plant Evodia rutaecarpa, which has long been used for treating infection-related diseases including diarrhea, beriberi and oral ulcer, but the underlying mechanism is unclear. Here we aimed to explore whether evodiamine influenced NLRP3 (NLR family, pyrin cont...