NOX2-Induced Activation of Arginase and Diabetes-Induced Retinal Endothelial Cell Senescence

• Main Authors: Modesto Rojas (Author), Tahira Lemtalsi (Author), Haroldo A. Toque (Author), Zhimin Xu (Author), David Fulton (Author), Robert William Caldwell (Author), Ruth B. Caldwell (Author)
• Format: Book
• Published: MDPI AG, 2017-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Increases in reactive oxygen species (ROS) and decreases in nitric oxide (NO) have been linked to vascular dysfunction during diabetic retinopathy (DR). Diabetes can reduce NO by increasing ROS and by increasing activity of arginase, which competes with nitric oxide synthase (NOS) for their commons...