Repression of Activated Aryl Hydrocarbon Receptor-Induced Transcriptional Activation by 5α-Dihydrotestosterone in Human Prostate Cancer LNCaP and Human Breast Cancer T47D Cells

• Main Authors: Noriko Sanada (Author), Yuka Gotoh (Author), Rumiko Shimazawa (Author), Carolyn M. Klinge (Author), Ryoichi Kizu (Author)
• Formato: Livro
• Publicado em: Elsevier, 2009-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Polycyclic aromatic hydrocarbons (PAHs) and dioxins are ubiquitous environmental pollutants and activate the aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor. It has been reported that testosterone represses 2,3,7,8-tetrachlorodibenzo-p-dioxin- induced transcription of the cy...