PBPK Modeling of Azithromycin Systemic Exposure in a Roux-en-Y Gastric Bypass Surgery Patient Population

• Main Authors: Suvarchala Kiranmai Avvari (Author), Jaclyn A. Cusumano (Author), Vamshi Krishna Jogiraju (Author), Pooja Manchandani (Author), David R. Taft (Author)
• Format: Book
• Published: MDPI AG, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this investigation, PBPK modeling using the Simcyp^® Simulator was performed to evaluate whether Roux-en-Y gastric bypass (RYGB) surgery impacts the oral absorption and bioavailability of azithromycin. An RYGB surgery patient population was adapted from the published literat...