CELLULAR RESPONSES TO DNA DAMAGE AND ONCOGENESIS BY THE p53 AND pRb/E2F PATHWAYS

• Main Authors: Elza Ibrahim Auerkari (Author), Ismu Suharsono Suwelo (Author), Achmad Tjarta (Author), Santoso Cornain (Author), T. W. Rahardjo (Author), K. Eto (Author), M.A. Ikeda (Author)
• Format: Book
• Published: Faculty of Dentistry, Universitas Indonesia, 2015-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cellular responses to stress including DNA damage, show multiple options involving the mechanisms of growth arrest. DNA repair and programmed cell death or apoptosis. Failures in these mechanisms can result in oncogenesis or accelerated senescence. Much of the response is coordinated by p53, a nucle...