Cardiomyocyte-specific conditional knockout of the histone chaperone HIRA in mice results in hypertrophy, sarcolemmal damage and focal replacement fibrosis

• Main Authors: Nicolas Valenzuela (Author), Qiying Fan (Author), Faisal Fa'ak (Author), Benjamin Soibam (Author), Harika Nagandla (Author), Yu Liu (Author), Robert J. Schwartz (Author), Bradley K. McConnell (Author), M. David Stewart (Author)
• Format: Book
• Published: The Company of Biologists, 2016-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

HIRA is the histone chaperone responsible for replication-independent incorporation of histone variant H3.3 within gene bodies and regulatory regions of actively transcribed genes, and within the bivalent promoter regions of developmentally regulated genes. The HIRA gene lies within the 22q11.2 dele...