The melanocortin pathway and energy homeostasis: From discovery to obesity therapy

• Main Authors: Giles S.H. Yeo (Author), Daniela Herrera Moro Chao (Author), Anna-Maria Siegert (Author), Zoe M. Koerperich (Author), Mark D. Ericson (Author), Stephanie E. Simonds (Author), Courtney M. Larson (Author), Serge Luquet (Author), Iain Clarke (Author), Shubh Sharma (Author), Karine Clément (Author), Michael A. Cowley (Author), Carrie Haskell-Luevano (Author), Lex Van Der Ploeg (Author), Roger A.H. Adan (Author)
• Format: Book
• Published: Elsevier, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Over the past 20 years, insights from human and mouse genetics have illuminated the central role of the brain leptin-melanocortin pathway in controlling mammalian food intake, with genetic disruption resulting in extreme obesity, and more subtle polymorphic variations influencing the pop...