MicroRNA-223 Suppresses IL-1β and TNF-α Production in Gouty Inflammation by Targeting the NLRP3 Inflammasome

• Main Authors: Quan-Bo Zhang (Author), Dan Zhu (Author), Fei Dai (Author), Yu-Qin Huang (Author), Jian-Xiong Zheng (Author), Yi-Ping Tang (Author), Zeng-Rong Dong (Author), Xia Liao (Author), Yu-Feng Qing (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: MicroRNA-223 (MiR-223) serves as an important regulator of inflammatory and immune responses and is implicated in several auto-inflammatory disorders. Here, we measured miR-223 expression in acute and intercritical gout patients, after which we used RAW264.7 macrophages transfected wit...