To blind or not to blind first in human and exploratory clinical trials: Acceleration of development vs. risk of bias

• Main Authors: Sebastian Haertter (Author), Jitendar Kanodia (Author), Jack Cook (Author), Jeanette Alicea (Author), Bonnie J. Brennan (Author), Amit Desai (Author), Bela Patel (Author), Lin Pan (Author), Kosalaram Goteti (Author)
• Format: Book
• Published: Wiley, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract An IQ consortium working group (WG) conducted a survey across multiple biopharmaceutical companies to gain information about the level of blinding commonly utilized for early clinical development trials. The main objectives were: (1) to understand blinding practices between healthy voluntee...