Contributions of Hepatic Gluconeogenesis Suppression and Compensative Glycogenolysis on the Glucose-Lowering Effect of CS-917, a Fructose 1,6-Bisphosphatase Inhibitor, in Non-obese Type 2 Diabetes Goto-Kakizaki Rats

• Main Authors: Taishi Yoshida (Author), Akira Okuno (Author), Kanako Takahashi (Author), Junko Ogawa (Author), Yuka Hagisawa (Author), Shoichi Kanda (Author), Toshihiko Fujiwara (Author)
• Formato: Libro
• Publicado: Elsevier, 2011-01-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Contributions of gluconeogenesis suppression in liver, kidney, and intestine as major gluconeogenic organs to the glucose-lowering effect of CS-917, a fructose 1,6-bisphosphatase inhibitor, was evaluated in overnight-fasted Goto-Kakizaki (GK) rats. CS-917 decreased plasma glucose by suppressing gluc...