Putting bicarbonate on the spot: pharmacological insights for CFTR correction in the airway epithelium

• Prif Awduron: Miroslaw Zajac (Awdur), Agathe Lepissier (Awdur), Elise Dréano (Awdur), Benoit Chevalier (Awdur), Aurélie Hatton (Awdur), Mairead Kelly-Aubert (Awdur), Daniela Guidone (Awdur), Gabrielle Planelles (Awdur), Aleksander Edelman (Awdur), Emmanuelle Girodon (Awdur), Alexandre Hinzpeter (Awdur), Gilles Crambert (Awdur), Iwona Pranke (Awdur), Luis. J. V. Galietta (Awdur), Isabelle Sermet-Gaudelus (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Frontiers Media S.A., 2023-12-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Introduction: Cystic fibrosis (CF) is caused by defective Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) proteins. CFTR controls chloride (Cl−) and bicarbonate (HCO3−) transport into the Airway Surface Liquid (ASL). We investigated the impact of F508del-CFTR correction on HCO3− secretion...