Putting bicarbonate on the spot: pharmacological insights for CFTR correction in the airway epithelium

Putting bicarbonate on the spot: pharmacological insights for CFTR correction in the airway epithelium

Introduction: Cystic fibrosis (CF) is caused by defective Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) proteins. CFTR controls chloride (Cl−) and bicarbonate (HCO3−) transport into the Airway Surface Liquid (ASL). We investigated the impact of F508del-CFTR correction on HCO3− secretion...

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Main Authors: Miroslaw Zajac (Author), Agathe Lepissier (Author), Elise Dréano (Author), Benoit Chevalier (Author), Aurélie Hatton (Author), Mairead Kelly-Aubert (Author), Daniela Guidone (Author), Gabrielle Planelles (Author), Aleksander Edelman (Author), Emmanuelle Girodon (Author), Alexandre Hinzpeter (Author), Gilles Crambert (Author), Iwona Pranke (Author), Luis. J. V. Galietta (Author), Isabelle Sermet-Gaudelus (Author)
Format: Book
Published: Frontiers Media S.A., 2023-12-01T00:00:00Z.
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