Comparative Assessment and High-Throughput Drug-Combination Profiling of TEAD-Palmitoylation Inhibitors in Hippo Pathway Deficient Mesothelioma

• Những tác giả chính: Lale Evsen (Tác giả), Patrick J. Morris (Tác giả), Craig J. Thomas (Tác giả), Michele Ceribelli (Tác giả)
• Định dạng: Sách
• Được phát hành: MDPI AG, 2023-11-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

The hippo signaling pathway is a central tumor suppressor cascade frequently inactivated in selected human cancers, leading to the aberrant activation of TEAD transcription factors. Whereas several TEAD auto-palmitoylation inhibitors are currently in development, a comprehensive assessment of this n...