Development of Metronidazole Loaded Chitosan Nanoparticles Using QbD Approach-A Novel and Potential Antibacterial Formulation

• Main Authors: Nagaraja Sreeharsha (Author), Kuldeep Rajpoot (Author), Muktika Tekade (Author), Dnyaneshwar Kalyane (Author), Anroop B. Nair (Author), Katharigatta N. Venugopala (Author), Rakesh K. Tekade (Author)
• Format: Book
• Published: MDPI AG, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The aim of this study was to design, optimize, and develop metronidazole (Met) loaded nanoparticles (MetNp) by employing quality-based design (QbD) as well as a risk assessment methodology. A fractional factorial design was used by selecting five independent variables viz., chitosan concentration, t...