Variability in Loss of Multiple Enzyme Activities Due to the Human Genetic Variation P284T Located in the Flexible Hinge Region of NADPH Cytochrome P450 Oxidoreductase

• Главные авторы: Shaheena Parween (Автор), Maria Natalia Rojas Velazquez (Автор), Sameer S. Udhane (Автор), Norio Kagawa (Автор), Amit V. Pandey (Автор)
• Формат: ‌
• Опубликовано: Frontiers Media S.A., 2019-10-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

Cytochromes P450 located in the endoplasmic reticulum require NADPH cytochrome P450 oxidoreductase (POR) for their catalytic activities. Mutations in POR cause multiple disorders in humans related to the biosynthesis of steroid hormones and also affect drug-metabolizing cytochrome P450 activities. E...