Design, synthesis, molecular docking, and molecular dynamic studies of novel quinazoline derivatives as phosphodiesterase 7 inhibitors

• Main Authors: Afaf A. El-Malah (Author), Magdy M. Gineinah (Author), Maan T. Khayat (Author), Anfal S. Aljahdali (Author), Marwa M. Safar (Author), Hadeel A. Almazmumi (Author), Roaa M. Khinkar (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Phosphodiesterase 7 (PDE7) is a high-affinity cyclic AMP (cAMP)-specific PDE that is expressed in immune and proinflammatory cells. In this work, we explore the possibility that selective small molecule inhibitors of this enzyme family could provide a novel approach to alleviate the in...