Possible Involvement of Endogenous 5-HT in Aggravation of Cerulein-Induced Acute Pancreatitis in Mice

• Main Authors: Kentaro Hamada (Author), Masanori Yoshida (Author), Hiroyuki Isayama (Author), Yoshiki Yagi (Author), Shuichi Kanazashi (Author), Yasunari Kashihara (Author), Koji Takeuchi (Author), Isamu Yamaguchi (Author)
• Format: Book
• Published: Elsevier, 2007-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The aim of the present study was to elucidate the pathogenic role of endogenous 5-HT in pancreatitis. Injections of cerulein at hourly intervals caused edematous pancreatitis in mice characterized by hyperenzymemia and histological alterations. While the cerulein-induced hyperenzymemia was attenuate...