Synthesis of new pyridothienopyrimidinone and pyridothienotriazolopyrimidine derivatives as pim-1 inhibitors

• Hauptverfasser: Hala B. El-Nassan (VerfasserIn), Bassem H. Naguib (VerfasserIn), Engy A. Beshay (VerfasserIn)
• Format: Buch
• Veröffentlicht: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Schlagworte: article
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Three series of 2-arylpyridothieno[3,2-d]pyrimidin-4-ones 3a-j, pyridothienotriazolopyrimidines 6-8 and 4-imino-pyridothieno[3,2-d]pyrimidines 9a,b were prepared to improve the pim-1 inhibitory activity of the previously reported 2-arylpyridothieno[3,2-d]pyrimidin-4-ones. All the test compounds show...