Genetic, physiological and comparative genomic studies of hypertension and insulin resistance in the spontaneously hypertensive rat

• Main Authors: Philip M. Coan (Author), Oliver Hummel (Author), Ana Garcia Diaz (Author), Marjorie Barrier (Author), Neza Alfazema (Author), Penny J. Norsworthy (Author), Michal Pravenec (Author), Enrico Petretto (Author), Norbert Hübner (Author), Timothy J. Aitman (Author)
• Format: Book
• Published: The Company of Biologists, 2017-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We previously mapped hypertension-related insulin resistance quantitative trait loci (QTLs) to rat chromosomes 4, 12 and 16 using adipocytes from F2 crosses between spontaneously hypertensive (SHR) and Wistar Kyoto (WKY) rats, and subsequently identified Cd36 as the gene underlying the chromosome 4...