Antidotal treatment of botulism in rats by continuous infusion with 3,4-diaminopyridine

• Main Authors: James B. Machamer (Author), Edwin J. Vazquez-Cintron (Author), Sean W. O'Brien (Author), Kyle E. Kelly (Author), Amber C. Altvater (Author), Kathleen T. Pagarigan (Author), Parker B. Dubee (Author), Celinia A. Ondeck (Author), Patrick M. McNutt (Author)
• Format: Book
• Published: BMC, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Botulinum neurotoxins (BoNTs) are highly potent, select agent toxins that inhibit neurotransmitter release at motor nerve terminals, causing muscle paralysis and death by asphyxiation. Other than post-exposure prophylaxis with antitoxin, the only treatment option for symptomatic botulism is...