Inhibition of post-trabeculectomy fibrosis via topically instilled antisense oligonucleotide complexes co-loaded with fluorouracil

• Main Authors: Kuan Jiang (Author), Junyi Chen (Author), Lingyu Tai (Author), Chang Liu (Author), Xishan Chen (Author), Gang Wei (Author), Weiyue Lu (Author), Weisan Pan (Author)
• Format: Book
• Published: Elsevier, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Trabeculectomy is the mainstay of surgical glaucoma treatment, while the success rate was unsatisfying due to postoperative scarring of the filtering blebs. Clinical countermeasures for scar prevention are intraoperative intervention or repeated subconjunctival injections. Herein, we designed a co-d...