Autocrine insulin-like growth factor 2 signaling as a potential target in the associated development of pulmonary emphysema and cancer in smokers

• Egile Nagusiak: Hye-Jin Boo (Egilea), Hye-Young Min (Egilea), Heung-Bin Lim (Egilea), Euni Lee (Egilea), Ho-Young Lee (Egilea)
• Formatua: Liburua
• Argitaratua: BMC, 2024-06-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Abstract Background Tobacco smoking causes pulmonary inflammation, resulting in emphysema, an independent risk factor for lung cancer. Induction of insulin-like growth factor 2 (IGF2) in response to lung injury by tobacco carcinogens, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol and polycyclic arom...