Involvement of µ-opioid Receptors and κ-opioid Receptors in Itch-related Scratching Behaviour of Imiquimod-induced Psoriasis-like Dermatitis in Mice

• Main Authors: Nobuaki Takahashi (Author), Mitsutoshi Tominaga (Author), Ryohei Kosaka (Author), Yayoi Kamata (Author), Yoshie Umehara (Author), Hironori Matsuda (Author), Azumi Sakaguchi (Author), Hideoki Ogawa (Author), Kenji Takamori (Author)
• Format: Book
• Published: Medical Journals Sweden, 2017-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The pathogenesis of psoriatic itch is poorly understood. The aim of this study was to investigate the involvement of opioid receptors in scratching behaviour of imiquimod-induced psoriasis-like dermatitis model mice. Topical application of 5% imiquimod cream to the rostral back skin of mice induced...