Transforming growth factor-β1/Smad/connective tissue growth factor axis: The main pathway in radiation-induced fibrosis of osteoradionecrosis?

• Hauptverfasser: Qian Wei Zhuang (Verfasst von), Zhi Yuan Zhang (Verfasst von), Guang Long Liu (Verfasst von), Shui Ting Fu (Verfasst von), Yue He (Verfasst von)
• Format: Buch
• Veröffentlicht: Wolters Kluwer Medknow Publications, 2013-01-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Introduction: Osteoradionecrosis (ORN) of the mandible is a serious complication following radiation therapy for malignancies of the head and neck. Radiation-induced fibrosis (RIF) is a new theory that accounts for the damage to normal tissues after radiotherapy, and the radiation-induced fibroatrop...