Biochemical properties of a novel cysteine protease of Plasmodium vivax, vivapain-4.

• Main Authors: Byoung-Kuk Na (Author), Young-An Bae (Author), Young-Gun Zo (Author), Youngchool Choe (Author), Seon-Hee Kim (Author), Prashant V Desai (Author), Mitchell A Avery (Author), Charles S Craik (Author), Tong-Soo Kim (Author), Philip J Rosenthal (Author), Yoon Kong (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2010-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Multiple cysteine proteases of malaria parasites are required for maintenance of parasite metabolic homeostasis and egress from the host erythrocyte. In Plasmodium falciparum these proteases appear to mediate the processing of hemoglobin and aspartic proteases (plasmepsins) in the acidic food vacuol...