2-aminobenzimidazoles for leishmaniasis: From initial hit discovery to in vivo profiling.

• Main Authors: Rafael Augusto Alves Ferreira (Author), Celso de Oliveira Rezende Junior (Author), Pablo David Grigol Martinez (Author), Paul John Koovits (Author), Bruna Miranda Soares (Author), Leonardo L G Ferreira (Author), Simone Michelan-Duarte (Author), Rafael Consolin Chelucci (Author), Adriano D Andricopulo (Author), Mariana K Galuppo (Author), Silvia R B Uliana (Author), An Matheeussen (Author), Guy Caljon (Author), Louis Maes (Author), Simon Campbell (Author), Jadel M Kratz (Author), Charles E Mowbray (Author), Luiz Carlos Dias (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Leishmaniasis is a major infectious disease with hundreds of thousands of new cases and over 20,000 deaths each year. The current drugs to treat this life-threatening infection have several drawbacks such as toxicity and long treatment regimens. A library of 1.8 million compounds, from which the hit...