Ciprofloxacin Affects Host Cells by Suppressing Expression of the Endogenous Antimicrobial Peptides Cathelicidins and Beta-Defensin-3 in Colon Epithelia

• Main Authors: Protim Sarker (Author), Akhirunnesa Mily (Author), Abdullah Al Mamun (Author), Shah Jalal (Author), Peter Bergman (Author), Rubhana Raqib (Author), Gudmundur H. Gudmundsson (Author), Birgitta Agerberth (Author)
• Format: Book
• Published: MDPI AG, 2014-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Antibiotics exert several effects on host cells including regulation of immune components. Antimicrobial peptides (AMPs), e.g., cathelicidins and defensins display multiple functions in innate immunity. In colonic mucosa, cathelicidins are induced by butyrate, a bacterial fermentation product. Here,...