Tanshinone I exerts cardiovascular protective effects in vivo and in vitro through inhibiting necroptosis via Akt/Nrf2 signaling pathway

• Main Authors: Youqiong Zhuo (Author), Renyikun Yuan (Author), Xinxin Chen (Author), Jia He (Author), Yangling Chen (Author), Chenwei Zhang (Author), Kaili Sun (Author), Shilin Yang (Author), Zhenjie Liu (Author), Hongwei Gao (Author)
• Format: Book
• Published: BMC, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Tanshinone I (TI) is a primary component of Salvia miltiorrhiza Bunge (Danshen), which confers a favorable role in a variety of pharmacological activities including cardiovascular protection. However, the exact mechanism of the cardiovascular protection activity of TI remains to...