ATL I, Acts as a SIRT6 Activator to Alleviate Hepatic Steatosis in Mice via Suppression of NLRP3 Inflammasome Formation

• Main Authors: Danli Kong (Author), Zhenhua Mai (Author), Yongze Chen (Author), Ling Luo (Author), Hao Liu (Author), Le Zhao (Author), Ruixian Huang (Author), Shuang Wang (Author), Rong Chen (Author), Hao Zhou (Author), Hao Chen (Author), Jingjing Zhang (Author), Haibing Yu (Author), Yuanlin Ding (Author)
• Format: Book
• Published: MDPI AG, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Accumulating evidence has highlighted that sirtuin-6 (SIRT6) plays an important role in hepatic gluconeogenesis and lipogenesis. We aim to investigate the underlying mechanisms and pharmacological interventions of SIRT6 on hepatic steatosis treatment. Herein, our results showed that atractylenolide...