Development and Evaluation of a Physiologically Based Pharmacokinetic Model for Predicting Haloperidol Exposure in Healthy and Disease Populations

• Main Authors: Mohammed S. Alasmari (Author), Fawaz Alasmari (Author), Abdullah F. Alasmari (Author), Aws Alshamsan (Author), Sary Alsanea (Author), Muhammad F. Rasool (Author), Faleh Alqahtani (Author)
• Format: Book
• Published: MDPI AG, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The physiologically based pharmacokinetic (PBPK) approach can be used to develop mathematical models for predicting the absorption, distribution, metabolism, and elimination (ADME) of administered drugs in virtual human populations. Haloperidol is a typical antipsychotic drug with a narrow therapeut...