Natural Activators of Autophagy Increase Maximal Walking Distance and Reduce Oxidative Stress in Patients with Peripheral Artery Disease: A Pilot Study

• Main Authors: Ombretta Martinelli (Author), Mariangela Peruzzi (Author), Simona Bartimoccia (Author), Alessandra D'Amico (Author), Simona Marchitti (Author), Speranza Rubattu (Author), Giovanni Alfonso Chiariello (Author), Luca D'Ambrosio (Author), Sonia Schiavon (Author), Fabio Miraldi (Author), Wael Saade (Author), Mizar D'Abramo (Author), Annachiara Pingitore (Author), Lorenzo Loffredo (Author), Cristina Nocella (Author), Maurizio Forte (Author), Pasquale Pignatelli (Author)
• Format: Book
• Published: MDPI AG, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Trehalose, spermidine, nicotinamide, and polyphenols have been shown to display pro-autophagic and antioxidant properties, eventually reducing cardiovascular and ischemic complications. This study aimed to investigate whether a mixture of these components improves maximal walking distance (MWD) in p...