The Effect of a Novel Serine Protease Inhibitor on Inflammation and Intestinal Permeability in a Murine Colitis Transfer Model

• Main Authors: Hanne Van Spaendonk (Author), Hannah Ceuleers (Author), Annemieke Smet (Author), Maya Berg (Author), Jurgen Joossens (Author), Pieter Van der Veken (Author), Sven M. Francque (Author), Anne-Marie Lambeir (Author), Joris G. De Man (Author), Ingrid De Meester (Author), Koen Augustyns (Author), Benedicte Y. De Winter (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: A protease/antiprotease disbalance is observed in inflammatory bowel diseases (IBD). We therefore studied the effect of the novel serine protease inhibitor UAMC-00050 on intestinal inflammation and permeability in a chronic colitis T cell transfer mouse model to get further insight into...