Strategies to overcome drug resistance using SHP2 inhibitors

• Main Authors: Meng Liu (Author), Shan Gao (Author), Reham M. Elhassan (Author), Xuben Hou (Author), Hao Fang (Author)
• Format: Book
• Published: Elsevier, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Encoded by PTPN11, the SHP2 (Src homology-2 domain-containing protein tyrosine phosphatase-2) is widely recognized as a carcinogenic phosphatase. As a promising anti-cancer drug target, SHP2 regulates many signaling pathways such as RAS-RAF-ERK, PI3K-AKT and JAK-STAT. Meanwhile, SHP2 plays a signifi...