Genetic variants of ABCB1 and CES1 genes on dabigatran metabolism in the Kazakh population

• Main Authors: Ayan Abdrakhmanov (Author), Elena Zholdybayeva (Author), Aizhana Shaimerdinova (Author), Gulmira Kulmambetova (Author), Svetlana Abildinova (Author), Rustam Albayev (Author), Gulnara Tuyakova (Author), Elena Rib (Author), Zhanasyl Suleimen (Author), Zhanar Abdrakhmanova (Author), Makhabbat Bekbossynova (Author)
• Format: Book
• Published: Babol University of Medical Sciences, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Allelic variants of genes encoding enzymes of the esterase system (CES1) and P-glycoprotein (ABCB1) can change the metabolism and pharmacokinetics of dabigatran. Therefore, they act as determining factors in the development of side effects, especially bleeding. We analyzed the genotype-p...