Gene Expression Profiling Reveals Complex Changes in the Olfactory Bulbectomy Model of Depression After Chronic Treatment With Antidepressants

• Main Authors: Kou Takahashi (Author), Akiyoshi Saitoh (Author), Misa Yamada (Author), Yoshiaki Maruyama (Author), Noritaka Hirose (Author), Junzo Kamei (Author), Mitsuhiko Yamada (Author)
• Format: Book
• Published: Elsevier, 2008-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We investigated the effects of antidepressants on the gene expression profile and behavior of olfactory-bulbectomized (OBX) rats. Removal of the main olfactory bulbs in rats alters neuronal function in brain areas involved in emotional regulation, resulting in maladaptive behavioral patterns similar...