Atractylenolide I Ameliorates Acetaminophen-Induced Acute Liver Injury via the TLR4/MAPKs/NF-κB Signaling Pathways

• Main Authors: Zhongyan Du (Author), Zhimei Ma (Author), Shanglei Lai (Author), Qinchao Ding (Author), Ziyi Hu (Author), Wenwen Yang (Author), Qianyu Qian (Author), Linwensi Zhu (Author), Xiaobing Dou (Author), Songtao Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Acetaminophen (APAP) overdose results in the production of reactive oxygen species (ROS), induces hepatocyte necrosis, and leads to acute liver failure. Atractylenolide I (AO-I), a phytochemical found in Atractylodes macrocephala Koidz, is known to exhibit antioxidant activity. However,...