Placental CD4+ T cells from preeclamptic patients cause autoantibodies to the angiotensin II type I receptor and hypertension in a pregnant rat model of preeclampsia

• Main Authors: Kristin E. Reeve (Author), Evangeline Deer (Author), Lorena M. Amaral (Author), Denise C. Cornelius (Author), Owen Herrock (Author), Ashlyn C. Harmon (Author), Nathan Campbell (Author), Sarah Fitzgerald (Author), Tarek Ibrahim (Author), Gerd Wallukat (Author), Ralf Dechend (Author), Babbette LaMarca (Author)
• Format: Book
• Published: Open Exploration Publishing Inc., 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aim: Preeclampsia (PE) is a hypertensive disorder of pregnancy associated with activated CD4+ T cells and autoantibodies to angiotensin II type 1 receptor (AT1-AA). We have previously shown that CD4+ T cells isolated from women with PE cause hypertension, increased tumor necrosis factor alpha (TNF-α...