The mitochondrial tRNA-derived fragment, mt-tRF-LeuTAA, couples mitochondrial metabolism to insulin secretion

• Main Authors: Cecile Jacovetti (Author), Chris Donnelly (Author), Véronique Menoud (Author), Mara Suleiman (Author), Cristina Cosentino (Author), Jonathan Sobel (Author), Kejing Wu (Author), Karim Bouzakri (Author), Piero Marchetti (Author), Claudiane Guay (Author), Bengt Kayser (Author), Romano Regazzi (Author)
• Format: Book
• Published: Elsevier, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The contribution of the mitochondrial electron transfer system to insulin secretion involves more than just energy provision. We identified a small RNA fragment (mt-tRF-LeuTAA) derived from the cleavage of a mitochondrially-encoded tRNA that is conserved between mice and humans. The role...