Development of an Intranasal In Situ System for Ribavirin Delivery: In Vitro and In Vivo Evaluation

• Main Authors: Iosif B. Mikhel (Author), Elena O. Bakhrushina (Author), Danila A. Petrusevich (Author), Andrey A. Nedorubov (Author), Svetlana A. Appolonova (Author), Natalia E. Moskaleva (Author), Natalia B. Demina (Author), Svetlana I. Kosenkova (Author), Mikhail A. Parshenkov (Author), Ivan I. Krasnyuk (Author)
• Format: Book
• Published: MDPI AG, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Recently, ribavirin has demonstrated effectiveness in treating glioblastoma through intranasal administration utilizing the nose-to-brain delivery route. Enhancing ribavirin's bioavailability can be achieved by utilizing intranasal stimuli-responsive systems that create a gel on the nasal mucos...