Adenosine-to-Inosine Editing of Vasoactive MicroRNAs Alters Their Targetome and Function in Ischemia

• Main Authors: Reginald V.C.T. van der Kwast (Author), Laura Parma (Author), M. Leontien van der Bent (Author), Eva van Ingen (Author), Fabiana Baganha (Author), Hendrika A.B. Peters (Author), Eveline A.C. Goossens (Author), Karin H. Simons (Author), Meindert Palmen (Author), Margreet R. de Vries (Author), Paul H.A. Quax (Author), A. Yaël Nossent (Author)
• Format: Book
• Published: Elsevier, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Adenosine-to-inosine (A-to-I) editing in the seed sequence of microRNAs can shift the microRNAs' targetomes and thus their function. Using public RNA-sequencing data, we identified 35 vasoactive microRNAs that are A-to-I edited. We quantified A-to-I editing of the primary (pri-)microRNAs in vas...