Isoforskolin modulates AQP4-SPP1-PIK3C3 related pathway for chronic obstructive pulmonary disease via cAMP signaling

• Main Authors: Haochang Lin (Author), Sha Cheng (Author), Songye Yang (Author), Qian Zhang (Author), Lueli Wang (Author), Jiangya Li (Author), Xinyue Zhang (Author), Liju Liang (Author), Xiaoqian Zhou (Author), Furong Yang (Author), Jingfeng Song (Author), Xue Cao (Author), Weimin Yang (Author), Zhiying Weng (Author)
• Format: Book
• Published: BMC, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Cyclic adenosine monophosphate (cAMP) levels are directly activated by adenylate cyclase (AC) and play an anti-inflammatory role in chronic obstructive pulmonary disease (COPD). Previously, we have shown that isoforskolin (ISOF) can effectively activate AC1 and AC2 in vitro, impr...