Interplay of early negative life events, development of orbitofrontal cortical thickness and depression in young adulthood

• Main Authors: Lea L. Backhausen (Author), Jonas Granzow (Author), Juliane H. Fröhner (Author), Eric Artiges (Author), Marie‐Laure Paillère‐Martinot (Author), Hervé Lemaître (Author), Fabio Sticca (Author), Tobias Banaschewski (Author), Sylvane Desrivières (Author), Antoine Grigis (Author), Andreas Heinz (Author), Rüdiger Brühl (Author), Dimitri Papadopoulos‐Orfanos (Author), Luise Poustka (Author), Sarah Hohmann (Author), Lauren Robinson (Author), Henrik Walter (Author), Jeanne Winterer (Author), Gunter Schumann (Author), Jean‐Luc Martinot (Author), Michael N. Smolka (Author), Nora C. Vetter (Author), the IMAGEN Consortium (Author)
• Format: Book
• Published: Wiley, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Early negative life events (NLE) have long‐lasting influences on neurodevelopment and psychopathology. Reduced orbitofrontal cortex (OFC) thickness was frequently associated with NLE and depressive symptoms. OFC thinning might mediate the effect of NLE on depressive symptoms, alt...